Engineering Escherichia coli to produce nonribosomal peptide antibiotics

被引：8

作者：

Challis, Gregory L. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

NATURE CHEMICAL BIOLOGY | 2006年 / 2卷 / 08期

关键词：

D O I：

10.1038/nchembio0806-398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic manipulation of biosynthetic pathways is a useful method for producing analogs of complex bioactive metabolites, but this technique can be challenging when performed in the natural producer of the target compounds. Reconstruction of biosynthetic gene clusters in E. coli could be the key to rapid heterologous production of natural products and genetic manipulation of their biosynthetic pathways.

引用

页码：398 / 400

页数：4

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