Natural products from marine organisms and their associated microbes

被引:194
作者
König, GM [1 ]
Kehraus, S [1 ]
Seibert, SF [1 ]
Abdel-Lateff, A [1 ]
Müller, D [1 ]
机构
[1] Univ Bonn, Inst Pharmaceut Biol, D-53115 Bonn, Germany
关键词
biosynthesis; cyanobacteria; fungi; marine microorganisms; natural products;
D O I
10.1002/cbic.200500087
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The marine environment is distinguished by unique groups of organisms being the source of a wide array of fascinating structures. The enormous biodiversity of marine habitats is mirrored by the molecular diversity of secondary metabolites found in marine animals, plants and microbes. The recognition that many marine invertebrates contain endo- and epibiotic microorganisms and that some in vertebrate-derived natural products are structurally related to bacterial metabolites suggests a microbial origin for some of these compounds. Other marine natural products, however are clearly located in invertebrate tissue and microbial involvement in the biosynthetic process seems unlikely. The complexity of associations in marine organisms, especially in sponges, bryozoons and tunicates, makes it extremely difficult to definitively state the biosynthetic source of many marine natural products or to deduce their ecological significance. Whereas many symbiotic marine microorganisms cannot be isolated and cultured, numerous epi- and endobiotic marine fungi produce novel secondary metabolites in laboratory cultures. The potent biological activity of many marine natural products is of relevance for their ecological function but is also the basis of their biomedical I importance.
引用
收藏
页码:229 / 238
页数:10
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