Agrochelin, a new cytotoxic antibiotic from a marine Agrobacterium -: Taxonomy, fermentation, isolation, physico-chemical properties and biological activity

被引：9

作者：

Acebal, C

Cañedo, LM ^{[1
]}

Puentes, JLF

Baz, JP

Romero, F

de la Calle, F

Grávalos, MDG

Rodriguez, P

机构：

[1] Inst Biomar SA Pol Ind Leon, Edif CEI, Leon 24231, Spain

[2] Pharma Mar SA Calera, Madrid 28760, Spain

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 11期

关键词：

D O I：

10.7164/antibiotics.52.983

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Agrochelin, a new alkaloid cytotoxic substance, was produced by the fermentation of Agrobacterium sp. The compound was obtained from the bacterial cells by solvent extraction and purified by silica gel chromatography. Agrochelin (1) and its acetyl derivative (2) exhibited cytotoxic activity.

引用

页码：983 / 987

页数：5

共 11 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[2] [Anonymous], 1974, BACTERIAL CHARACTERS
[3] ANTINEOPLASTIC AND ANTIHERPETIC ACTIVITY OF SPERMIDINE CATECHOLAMIDE IRON CHELATORS
BERGERON, RJ
CAVANAUGH, PF
KLINE, SJ
HUGHES, RG
ELLIOTT, GT
PORTER, CW
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 121 (03) : 848 - 854
[4] Chambers CE, 1996, BIOMETALS, V9, P157
[5] DRECHSEL H, 1995, LIEBIGS ANN, P1727
[6] KERSTERS K, 1984, BERGEYS MANUAL SYSTE, V1, P244
[7] Micacocidin A, B and C, novel antimycoplasma agents from Pseudomonas sp. -: II.: Structure elucidation
Kobayashi, S
Nakai, H
Ikenishi, Y
Sun, WY
Ozaki, M
Hayase, Y
Takeda, R
[J]. JOURNAL OF ANTIBIOTICS, 1998, 51 (03) : 328 - 332
[8] Micacocidin A, B and C, novel antimycoplasma agents from Pseudomonassp. -: I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
Kobayashi, S
Hidaka, S
Kawamura, H
Ozaki, M
Hayase, Y
[J]. JOURNAL OF ANTIBIOTICS, 1998, 51 (03) : 323 - 327
[9] MARINE STAR-SHAPED-AGGREGATE-FORMING BACTERIA - AGROBACTERIUM-ATLANTICUM SP-NOV, AGROBACTERIUM-METEORI SP-NOV, AGROBACTERIUM-FERRUGINEUM SP-NOV, NOM-REV, AGROBACTERIUM-GELATINOVORUM SP-NOV, NOM-REV, AND AGROBACTERIUM-STELLULATUM SP-NOV, NOM-REV
RUGER, HJ
HOFLE, MG
[J]. INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1992, 42 (01): : 133 - 143
[10] VANDERAUWERA P, 1986, J MICROBIOL METH, V4, P265

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