A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder

被引:23
作者
Kirov, G
Norton, N
Jones, I
McCandless, F
Craddock, N
Owen, MJ
机构
[1] Univ Wales, Coll Med, Neuropsychiat Genet Unit, Cardiff CF4 4XN, S Glam, Wales
[2] Queen Elizabeth Psychiat Hosp, Dept Psychiat, Birmingham B15 2QZ, W Midlands, England
基金
英国医学研究理事会;
关键词
MAOA; MAOB; bipolar; genetic; rapid cycling;
D O I
10.1017/S1461145799001601
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The genes encoding for the enzymes monoamine oxidase (MAO) A and B are good candidates to investigate bipolar affective disorder. A 30 bp repeat in the MAOA promoter was recently demonstrated to be polymorphic and to affect transcriptional activity. In a family-based association design we found that none of the different repeat copies was preferentially transmitted from mothers (n = 131) to their children affected with bipolar disorder (chi(2) = 2.75, 4 d.f., p = 0.6). Following on our previous finding of an excess of low-activity genotypes of catechol-O-methyltransferase in patients with a rapid cycling form of illness, we examined for a similar trend with MAOA alleles. In an extended sample we found a non-significant trend for patients with an ultra-rapid cycling form of illness (n = 29) to have a higher frequency of low-activity alleles compared with 92 bipolar patients with a non-rapid cycling course of illness (chi(2) = 2.37, 1 d.f, p = 0.13).
引用
收藏
页码:293 / 298
页数:6
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