Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells

被引：134

作者：

Card, Catherine M. ^{[1
]}

McLaren, Paul J. ^{[1
]}

Wachihi, Charles ^{[3
]}

Kimani, Joshua ^{[3
]}

Plummer, Francis A. ^{[1
,2
]}

Fowke, Keith R. ^{[1
,3
]}

机构：

[1] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[2] Publ Hlth Agcy Canada, Winnipeg, MB, Canada

[3] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 199卷 / 09期

基金：

加拿大健康研究院;

关键词：

SUSCEPTIBILITY; TRANSMISSION;

D O I：

10.1086/597801

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels of immune activation may contribute to protection against infection. In the present study, HIV-resistant individuals were shown to have reduced frequencies of T cells expressing the activation marker CD69. They were also found to have elevated frequencies of regulatory T (T-reg) cells, compared with HIV-negative control individuals. By controlling levels of T cell activation, Treg cells may contribute to HIV resistance by minimizing the pool of cells susceptible to infection.

引用

页码：1318 / 1322

页数：5

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