Hypoxia-like tissue injury as a component of multiple sclerosis lesions

被引：166

作者：

Lassmann, H ^{[1
]}

机构：

[1] Univ Vienna, Brain Res Inst, Div Neuroimmunol, A-1090 Vienna, Austria

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2003年 / 206卷 / 02期

关键词：

multiple sclerosis; demyelination; axonal injury; hypoxia; vascular damage;

D O I：

10.1016/S0022-510X(02)00421-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent data suggest that the mechanisms of demyelination and tissue damage in multiple sclerosis (MS) are heterogenous. In this review, evidence is discussed, which show that in a subset of multiple sclerosis patients the central nervous system (CNS) lesions show profound similarities to tissue alterations found in acute white matter stroke, thus suggesting that a hypoxia-like metabolic injury is a pathogenetic component in a subset of inflammatory brain lesions. Both, vascular pathology as well as metabolic disturbances induced by toxins of activated macrophages and microglia may be responsible for such lesions in multiple sclerosis. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：187 / 191

页数：5

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