Targeting calcium signaling in cancer therapy

被引：415

作者：

Cui, Chaochu ^{[1
,2
,3
]}

Merritt, Robert ^{[3
,4
]}

Fu, Liwu ^{[1
,2
]}

Pan, Zui ^{[3
,4
,5
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China

[3] Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA

[4] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[5] Univ Texas Arlington, Coll Nursing & Hlth Innovat, LS Bldg 239,501 S Nedderman Dr, Arlington, TX 76019 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2017年 / 7卷 / 01期

关键词：

Ca2+ channels; Store-operated Ca2+ entry; Cell proliferation; Migration; Apoptosis; Channel blockers; Cancer therapy; ACTIVATED CA2+ CHANNELS; SQUAMOUS-CELL CARCINOMA; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; POTENTIAL VANILLOID-1 TRPV1; HUMAN OVARIAN-CANCER; HUMAN COLON-CANCER; MOLECULE; STIM2; BREAST-CANCER; PROSTATE-CANCER; ION-CHANNEL;

D O I：

10.1016/j.apsb.2016.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research

引用

页码：3 / 17

页数：15

共 210 条

[1] Ryanodine receptor expression correlates with tumor grade in breast cancer
Abdul, Mansoor
Ramlal, Sian
Hoosein, Naseema
[J]. PATHOLOGY & ONCOLOGY RESEARCH, 2008, 14 (02) : 157 - 160
[2] Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Adapala, R. K.
Thoppil, R. J.
Ghosh, K.
Cappelli, H. C.
Dudley, A. C.
Paruchuri, S.
Keshamouni, V.
Klagsbrun, M.
Meszaros, J. G.
Chilian, W. M.
Ingber, D. E.
Thodeti, C. K.
[J]. ONCOGENE, 2016, 35 (03) : 314 - 322
[3] Emerging Roles of P2X Receptors in Cancer
Adinolfi, Elena
Capece, Marina
Amoroso, Francesca
De Marchi, Elena
Franceschini, Alessia
[J]. CURRENT MEDICINAL CHEMISTRY, 2015, 22 (07) : 878 - 890
[4] Expression of P2X7 Receptor Increases In Vivo Tumor Growth
Adinolfi, Elena
Raffaghello, Lizzia
Giuliani, Anna Lisa
Cavazzini, Luigi
Capece, Marina
Chiozzi, Paola
Bianchi, Giovanna
Kroemer, Guido
Pistoia, Vito
Di Virgilio, Francesco
[J]. CANCER RESEARCH, 2012, 72 (12) : 2957 - 2969
[5] (-)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels
Akbulut, Yasemin
Gaunt, Hannah J.
Muraki, Katsuhiko
Ludlow, Melanie J.
Amer, Mohamed S.
Bruns, Alexander
Vasudev, Naveen S.
Radtke, Lea
Willot, Matthieu
Hahn, Sven
Seitz, Tobias
Ziegler, Slava
Christmann, Mathias
Beech, David J.
Waldmann, Herbert
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (12) : 3787 - 3791
[6] IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2
Akl, H.
Monaco, G.
La Rovere, R.
Welkenhuyzen, K.
Kiviluoto, S.
Vervliet, T.
Molgo, J.
Distelhorst, C. W.
Missiaen, L.
Mikoshiba, K.
Parys, J. B.
De Smedt, H.
Bultynck, G.
[J]. CELL DEATH & DISEASE, 2013, 4 : e632 - e632
[7] Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature
Almeida, M. Camila
Hew-Butler, Tamara
Soriano, Renato N.
Rao, Sara
Wang, Weiya
Wang, Judy
Tamayo, Nuria
Oliveira, Daniela L.
Nucci, Tatiane B.
Aryal, Prafulla
Garami, Andras
Bautista, Diana
Gavva, Narender R.
Romanovsky, Andrej A.
[J]. JOURNAL OF NEUROSCIENCE, 2012, 32 (06) : 2086 - 2099
[8] Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation
Aung, Cho S.
Kruger, Wade A.
Poronnik, Philip
Roberts-Thomson, Sarah J.
Monteith, Gregory R.
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 355 (04) : 932 - 936
[9] Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation
Ay, Anne-Sophie
Benzerdjerb, Nazim
Sevestre, Henri
Ahidouch, Ahmed
Ouadid-Ahidouch, Halima
[J]. PLOS ONE, 2013, 8 (09):
[10] Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy
Aydar, Ebru
Yeo, Syn
Djamgoz, Mustafa
Palmer, Christopher
[J]. CANCER CELL INTERNATIONAL, 2009, 9

← 1 2 3 4 5 6 7 8 9 10 →