Targeting calcium signaling in cancer therapy

被引：415

作者：

Cui, Chaochu ^{[1
,2
,3
]}

Merritt, Robert ^{[3
,4
]}

Fu, Liwu ^{[1
,2
]}

Pan, Zui ^{[3
,4
,5
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China

[3] Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA

[4] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[5] Univ Texas Arlington, Coll Nursing & Hlth Innovat, LS Bldg 239,501 S Nedderman Dr, Arlington, TX 76019 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2017年 / 7卷 / 01期

关键词：

Ca2+ channels; Store-operated Ca2+ entry; Cell proliferation; Migration; Apoptosis; Channel blockers; Cancer therapy; ACTIVATED CA2+ CHANNELS; SQUAMOUS-CELL CARCINOMA; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; POTENTIAL VANILLOID-1 TRPV1; HUMAN OVARIAN-CANCER; HUMAN COLON-CANCER; MOLECULE; STIM2; BREAST-CANCER; PROSTATE-CANCER; ION-CHANNEL;

D O I：

10.1016/j.apsb.2016.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research

引用

页码：3 / 17

页数：15

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