Targeting calcium signaling in cancer therapy

被引：415

作者：

Cui, Chaochu ^{[1
,2
,3
]}

Merritt, Robert ^{[3
,4
]}

Fu, Liwu ^{[1
,2
]}

Pan, Zui ^{[3
,4
,5
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China

[3] Ohio State Univ, Dept Surg, Div Thorac Dis, Columbus, OH 43210 USA

[4] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[5] Univ Texas Arlington, Coll Nursing & Hlth Innovat, LS Bldg 239,501 S Nedderman Dr, Arlington, TX 76019 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2017年 / 7卷 / 01期

关键词：

Ca2+ channels; Store-operated Ca2+ entry; Cell proliferation; Migration; Apoptosis; Channel blockers; Cancer therapy; ACTIVATED CA2+ CHANNELS; SQUAMOUS-CELL CARCINOMA; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; POTENTIAL VANILLOID-1 TRPV1; HUMAN OVARIAN-CANCER; HUMAN COLON-CANCER; MOLECULE; STIM2; BREAST-CANCER; PROSTATE-CANCER; ION-CHANNEL;

D O I：

10.1016/j.apsb.2016.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and death. Accumulating evidences have demonstrated that intracellular Ca2+ homeostasis is altered in cancer cells and the alteration is involved in tumor initiation, angiogenesis, progression and metastasis. Targeting derailed Ca2+ signaling for cancer therapy has become an emerging research area. This review summarizes some important Ca2+ channels, transporters and Ca2+-ATPases, which have been reported to be altered in human cancer patients. It discusses the current research effort toward evaluation of the blockers, inhibitors or regulators for Ca2+ channels/transporters or Ca2+-ATPase pumps as anti-cancer drugs. This review is also aimed to stimulate interest in, and support for research

引用

页码：3 / 17

页数：15

共 210 条

[21] KB-R7943, an inhibitor of the reverse Na+/Ca2+exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I
Brustovetsky, Tatiana
Brittain, Matthew K.
Sheets, Patrick L.
Cummins, Theodore R.
Pinelis, Vsevolod
Brustovetsky, Nickolay
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (01) : 255 - 270
[22] Cárdenas C, 2016, CELL REP, V14, P2313, DOI [10.1016/j.celrep.2016.03.045, 10.1016/j.celrep.2016.02.030]
[23] Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation
Carson, Cheryl
Raman, Pichai
Tullai, Jennifer
Xu, Lei
Henault, Martin
Thomas, Emily
Yeola, Sarita
Lao, Jianmin
McPate, Mark
Verkuyl, J. Martin
Marsh, George
Sarber, Jason
Amaral, Adam
Bailey, Scott
Lubicka, Danuta
Pham, Helen
Miranda, Nicolette
Ding, Jian
Tang, Hai-Ming
Ju, Haisong
Tranter, Pamela
Ji, Nan
Krastel, Philipp
Jain, Rishi K.
Schumacher, Andrew M.
Loureiro, Joseph J.
George, Elizabeth
Berellini, Giuliano
Ross, Nathan T.
Bushell, Simon M.
Erdemli, Guel
Solomon, Jonathan M.
[J]. PLOS ONE, 2015, 10 (06):
[24] Structure and regulation of voltage-gated Ca2+ channels
Catterall, WA
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 : 521 - 555
[25] A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Chen, Cheng-Chang
Keller, Marco
Hess, Martin
Schiffmann, Raphael
Urban, Nicole
Wolfgardt, Annette
Schaefer, Michael
Bracher, Franz
Biel, Martin
Wahl-Schott, Christian
Grimm, Christian
[J]. NATURE COMMUNICATIONS, 2014, 5
[26] Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions
Chen, Gang
Panicker, Sandip
Lau, Kai-Yeung
Apparsundaram, Subramaniam
Patel, Vaishali A.
Chen, Shiow-Ling
Soto, Rothschild
Jung, Jimmy K. C.
Ravindran, Palanikumar
Okuhara, Dayne
Bohnert, Gary
Che, Qinglin
Rao, Patricia E.
Allard, John D.
Badi, Laura
Bitter, Hans-Marcus
Nunn, Philip A.
Narula, Satwant K.
DeMartino, Julie A.
[J]. MOLECULAR IMMUNOLOGY, 2013, 54 (3-4) : 355 - 367
[27] Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
Chen, Yih-Fung
Chiu, Wen-Tai
Chen, Ying-Ting
Lin, Pey-Yun
Huang, Huey-Jy
Chou, Cheng-Yang
Chang, Hsien-Chang
Tang, Ming-Jer
Shen, Meng-Ru
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (37) : 15225 - 15230
[28] Estrogen regulation of TRPM8 expression in breast cancer cells
Chodon, Dechen
Guilbert, Arnaud
Dhennin-Duthille, Isabelle
Gautier, Mathieu
Telliez, Marie-Sophie
Sevestre, Henri
Ouadid-Ahidouch, Halima
[J]. BMC CANCER, 2010, 10
[29] Interplay between TRP channels and the cytoskeleton in health and disease
Clark, Kristopher
Middelbeek, Jeroen
van Leeuwen, Frank N.
[J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2008, 87 (8-9) : 631 - 640
[30] Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
Costa, B
Giagnoni, G
Franke, C
Trovato, AE
Colleoni, M
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (02) : 247 - 250

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