Recent advances in ion channel research

被引：82

作者：

Chung, SH ^{[1
]}

Kuyucak, S

机构：

[1] Australian Natl Univ, Fac Sci, Dept Phys, Prot Dynam Unit, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, Res Sch Phys Sci, Dept Theoret Phys, Canberra, ACT 0200, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2002年 / 1565卷 / 02期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

membrane ion channel; Brownian dynamics; molecular dynamics; channel modeling; theories of ion permeation;

D O I：

10.1016/S0005-2736(02)00574-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of ion channels has entered into a rapid phase of development in the last few years, partly due to the breakthroughs in determination of the crystal structures of membrane proteins and advances in computer simulation, of biomolecules. These advances have finally enabled the long-dreamed goal of relating function of a channel to its underlying molecular structure. Here we present simplified accounts of the competing permeation theories and then discuss their application to the potassium, gramicidin A and calcium channels. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：267 / 286

页数：20

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