Silk-inspired low-molecular-weight organogelator

被引：30

作者：

Escuder, Beatriu ^{[1
]}

Miravet, Juan F. ^{[1
]}

机构：

[1] Univ Jaume 1, Dept Quim Inorgan & Organ, Castellon de La Plana 12071, Spain

来源：

LANGMUIR | 2006年 / 22卷 / 18期

关键词：

D O I：

10.1021/la060499w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A minimal sequence from natural silks, the tetrapeptide GAGA, has been used as inspiration for the design of a new organogelator. Gels were obtained in several organic solvents, and their microscopic aspects were studied by transmission and cryo-scanning electron microscopies (TEM and cryo-SEM). FT-IR spectroscopy, circular dichroism, and wide-angle X-ray diffraction were used to study the self-assembly features of this molecule, and evidence of an antiparallel beta-sheet organization was obtained. Remarkably, the precise secondary structure uniqueness found in Nature was successfully transferred into a small synthetic analogue that self-assembles driven only by noncovalent interactions.

引用

页码：7793 / 7797

页数：5

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