Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD

被引：24

作者：

Jung, Da Hee ^{[1
,2
]}

Ahn, Sung Min ^{[3
]}

Pak, Malk Eun ^{[3
]}

Lee, Hong Ju ^{[1
,2
]}

Jung, Young Jin ^{[4
]}

Kim, Ki Bong ^{[5
]}

Shin, Yong-Il ^{[6
]}

Shin, Hwa Kyoung ^{[1
,2
,3
]}

Choi, Byung Tae ^{[1
,2
,3
]}

机构：

[1] Pusan Natl Univ, Sch Korean Med, Dept Korean Med Sci, Yangsan, South Korea

[2] Pusan Natl Univ, Grad Training Program Korean Med Hlth Aging, Yangsan, South Korea

[3] Pusan Natl Univ, Korean Med Sci Res Ctr Hlth Aging, Yangsan, South Korea

[4] Dongseo Univ, Div Hlth Sci, Dept Radiol Sci, Busan, South Korea

[5] Pusan Natl Univ, Sch Korean Med, Dept Korean Pediat, Yangsan, South Korea

[6] Pusan Natl Univ, Sch Med, Dept Rehabil Med, Yangsan, South Korea

来源：

ELIFE | 2020年 / 9卷

基金：

新加坡国家研究基金会;

关键词：

VESICULAR MONOAMINE TRANSPORTER-2; DEFICIT HYPERACTIVITY DISORDER; NEUROTROPHIC FACTOR; DOPAMINE RELEASE; ATTENTION; BRAIN; BDNF; SAFETY; MEMORY; METAANALYSIS;

D O I：

10.7554/eLife.56359

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive rats (SHR) were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 mu A, current density 63.7 A/m(2), charge density 76.4 kC/m(2)) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.

引用

页数：26

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