Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens

被引：80

作者：

Afkhami, Sam ^{[1
]}

Yao, Yushi ^{[1
]}

Xing, Zhou ^{[1
]}

机构：

[1] McMaster Univ, McMaster Immunol Res Ctr, Dept Pathol & Mol Med, Hamilton, ON, Canada

来源：

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | 2016年 / 3卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

T-CELL RESPONSES; CHIMPANZEE ADENOVIRUS; TUBERCULOSIS VACCINE; IMMUNE-RESPONSES; DOUBLE-BLIND; HIV-1; VACCINE; GENE-TRANSFER; RECOMBINANT ADENOVIRUSES; NEUTRALIZING ANTIBODIES; PROTECTIVE EFFICACY;

D O I：

10.1038/mtm.2016.30

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Adenoviruses represent the most widely used viral-vectored platform for vaccine design, showing a great potential in the fight against intracellular infectious diseases to which either there is a lack of effective vaccines or the traditional vaccination strategy is suboptimal. The extensive understanding of the molecular biology of adenoviruses has made the new technologies and reagents available to efficient generation of adenoviral-vectored vaccines for both preclinical and clinical evaluation. The novel adenoviral vectors including nonhuman adenoviral vectors have emerged to be the further improved vectors for vaccine design. In this review, we discuss the latest adenoviral technologies and their utilization in vaccine development. We particularly focus on the application of adenoviral-vectored vaccines in mucosal immunization strategies against mucosal pathogens including Mycobacterium tuberculosis, flu virus, and human immunodeficiency virus.

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