Structure and function of lipopolysaccharides

被引:504
作者
Erridge, C
Bennett-Guerrero, E
Poxton, IR [1 ]
机构
[1] Univ Edinburgh, Sch Med, Edinburgh EH8 9AG, Midlothian, Scotland
[2] Columbia Univ Coll Phys & Surg, Dept Anesthesiol, New York, NY 10032 USA
关键词
lipopolysaccharides; molecular structure; endotoxins;
D O I
10.1016/S1286-4579(02)01604-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The lipopolysaccharides of Gram-negative bacteria have a profound effect on the mammalian immune system and are of great significance in the pathophysiology of many disease processes. Consideration is given in this review to the relationship between structure and function of these lipopolysaccharides. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:837 / 851
页数:15
相关论文
共 82 条
  • [71] TAKADA H, 1992, BACTERIAL ENDOTOXIC, V1, P107
  • [72] TANAMOTO K, 1984, INFECT IMMUN, V44, P421, DOI 10.1128/IAI.44.2.421-426.1984
  • [73] Innate immune recognition of bacterial lipopolysaccharide: Dependence on interactions with membrane lipids and endocytic movement
    Thieblemont, N
    Thieringer, R
    Wright, SD
    [J]. IMMUNITY, 1998, 8 (06) : 771 - 777
  • [74] BIOLOGICAL-ACTIVITY OF SYNTHETIC PHOSPHONOOXYETHYL ANALOGS OF LIPID-A AND LIPID-A PARTIAL STRUCTURES
    ULMER, AJ
    HEINE, H
    FEIST, W
    KUSUMOTO, S
    KUSAMA, T
    BRADE, H
    SCHADE, U
    RIETSCHEL, ET
    FLAD, HD
    [J]. INFECTION AND IMMUNITY, 1992, 60 (08) : 3309 - 3314
  • [75] Toll-like receptors: key mediators of microbe detection
    Underhill, DM
    Ozinsky, A
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (01) : 103 - 110
  • [76] Internalization of monomeric lipopolysaccharide occurs after transfer out of cell surface CD14
    Vasselon, T
    Hailman, E
    Thieringer, R
    Detmers, PA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (04) : 509 - 521
  • [77] Viriyakosol S, 2001, J BIOL CHEM, V276, P38044
  • [78] Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    Werts, C
    Tapping, RI
    Mathison, JC
    Chuang, TH
    Kravchenko, V
    Saint Girons, I
    Haake, DA
    Godowski, PJ
    Hayashi, F
    Ozinsky, A
    Underhill, DM
    Kirschning, CJ
    Wagner, H
    Aderem, A
    Tobias, PS
    Ulevitch, RJ
    [J]. NATURE IMMUNOLOGY, 2001, 2 (04) : 346 - 352
  • [79] STUDIES OF LIPOPOLYSACCHARIDES FROM PSEUDOMONAS-AERUGINOSA
    WILKINSON, SG
    GALBRAITH, L
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1975, 52 (02): : 331 - 343
  • [80] Toll, a new piece in the puzzle of innate immunity
    Wright, SD
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (04) : 605 - 609