Variations on a theme: the alternate translocations in APL

被引:86
作者
Redner, RL
机构
[1] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Ctr Canc, Pittsburgh, PA 15213 USA
关键词
APL; PML-RAR; PLZF-RAR; NPM-RAR; NUMA-RAR; STAT5b-RAR;
D O I
10.1038/sj.leu.2402720
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR. In this review we will discuss these variant translocations, and discuss the insights that we have gained from their study.
引用
收藏
页码:1927 / 1932
页数:6
相关论文
共 61 条
  • [1] The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor α in acute promyelocytic-like leukaemia
    Arnould, C
    Philippe, C
    Bourdon, V
    Grégoire, MJ
    Berger, R
    Jonveaux, P
    [J]. HUMAN MOLECULAR GENETICS, 1999, 8 (09) : 1741 - 1749
  • [2] CHEN SJ, 1991, BLOOD, V78, P2696
  • [3] PLZF-RAR-ALPHA FUSION PROTEINS GENERATED FROM THE VARIANT T(11-17)(Q23-Q21) TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKEMIA INHIBIT LIGAND-DEPENDENT TRANSACTIVATION OF WILD-TYPE RETINOIC ACID RECEPTORS
    CHEN, Z
    GUIDEZ, F
    ROUSSELOT, P
    AGADIR, A
    CHEN, SJ
    WANG, ZY
    DEGOS, L
    ZELENT, A
    WAXMAN, S
    CHOMIENNE, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (03) : 1178 - 1182
  • [4] FUSION BETWEEN A NOVEL KRUPPEL-LIKE ZINC FINGER GENE AND THE RETINOIC ACID RECEPTOR-ALPHA LOCUS DUE TO A VARIANT T(11,17) TRANSLOCATION ASSOCIATED WITH ACUTE PROMYELOCYTIC LEUKEMIA
    CHEN, Z
    BRAND, NJ
    CHEN, A
    CHEN, SJ
    TONG, JH
    WANG, ZY
    WAXMAN, S
    ZELENT, A
    [J]. EMBO JOURNAL, 1993, 12 (03) : 1161 - 1167
  • [5] A VARIANT T(14-17) IN ACUTE PROMYELOCYTIC LEUKEMIA - POSITIVE RESPONSE TO RETINOIC ACID TREATMENT
    CIGUDOSA, JC
    CALASANZ, MJ
    ODERO, MD
    MARIN, J
    BENGOECHEA, E
    GULLON, A
    [J]. CANCER GENETICS AND CYTOGENETICS, 1995, 80 (02) : 160 - 161
  • [6] COREY SJ, 1994, LEUKEMIA, V8, P1350
  • [7] THE PML-RAR-ALPHA FUSION MESSENGER-RNA GENERATED BY THE T(15-17) TRANSLOCATION IN ACUTE PROMYELOCYTIC LEUKEMIA ENCODES A FUNCTIONALLY ALTERED RAR
    DETHE, H
    LAVAU, C
    MARCHIO, A
    CHOMIENNE, C
    DEGOS, L
    DEJEAN, A
    [J]. CELL, 1991, 66 (04) : 675 - 684
  • [8] THE T(15-17) TRANSLOCATION OF ACUTE PROMYELOCYTIC LEUKEMIA FUSES THE RETINOIC ACID RECEPTOR-ALPHA GENE TO A NOVEL TRANSCRIBED LOCUS
    DETHE, H
    CHOMIENNE, C
    LANOTTE, M
    DEGOS, L
    DEJEAN, A
    [J]. NATURE, 1990, 347 (6293) : 558 - 561
  • [9] Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
    Di Croce, L
    Raker, VA
    Corsaro, M
    Fazi, F
    Fanelli, M
    Faretta, M
    Fuks, F
    Lo Coco, F
    Kouzarides, T
    Nervi, C
    Minucci, S
    Pelicci, PG
    [J]. SCIENCE, 2002, 295 (5557) : 1079 - 1082
  • [10] Interactions of STAT5b-RARα, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways
    Dong, S
    Tweardy, DJ
    [J]. BLOOD, 2002, 99 (08) : 2637 - 2646