Circuit dynamics of adaptive and maladaptive behaviour

被引：122

作者：

Deisseroth, Karl ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

[3] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

NATURE | 2014年 / 505卷 / 7483期

关键词：

DEEP BRAIN-STIMULATION; LATERAL HABENULA; DOPAMINERGIC-NEURONS; OPTOGENETIC CONTROL; ANIMAL-MODELS; GAMMA RHYTHM; REWARD; AMYGDALA; CONNECTIVITY; NETWORKS;

D O I：

10.1038/nature12982

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recent development of technologies for investigating specific components of intact biological systems has allowed elucidation of the neural circuitry underlying adaptive and maladaptive behaviours. Investigators are now able to observe and control, with high spatio-temporal resolution, structurally defined intact pathways along which electrical activity flows during and after the performance of complex behaviours. These investigations have revealed that control of projection-specific dynamics is well suited to modulating behavioural patterns that are relevant to a broad range of psychiatric diseases. Structural dynamics principles have emerged to provide diverse, unexpected and causal insights into the operation of intact and diseased nervous systems, linking form and function in the brain.

引用

页码：309 / 317

页数：9

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