Understanding enediyne-protein interactions: Diyl atom transfer results in generation of aminoacyl radicals

被引：50

作者：

Jones, GB ^{[1
]}

Plourde, GW

Wright, JM

机构：

[1] Northeastern Univ, Dept Chem, Bioorgan Lab, Boston, MA 02115 USA

[2] Northeastern Univ, Dept Chem, Med Chem Labs, Boston, MA 02115 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 06期

关键词：

D O I：

10.1021/ol0055566

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodatively stabilized radicals.

引用

页码：811 / 813

页数：3

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