Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne

被引：18

作者：

Jones, GB

Kilgore, MW

Pollenz, RS

Li, AW

Mathews, JE

Wright, JM

Huber, RS

Tate, PL

Price, TL

Sticca, RP

机构：

[1] GREENVILLE HOSP SYST CLEMSON UNIV BIOMED COOPERAT,CLEMSON,SC 29634

[2] MED UNIV S CAROLINA,DEPT BIOCHEM & MOL BIOL,CHARLESTON,SC 29425

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00352-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient route to oxo-enediynes is presented. A simple oxo-enediyne has been synthesized, which cyclizes to give an isochroman. The agent shows cytotoxicity for ER rich breast cancer cells and a model for its mode of action is proposed. Copyright (C) 1996 Elsevier Science Ltd.

引用

收藏

页码：1971 / 1976

页数：6

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