学术探索
学术期刊
新闻热点
数据分析
智能评审

Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs

被引：47
作者：
Bailey, J [1 ]
Blankson, JN [1 ]
Wind-Rotolo, M [1 ]
Siliciano, RF [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21204 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 04期
关键词：
D O I：
10.1016/j.coi.2004.05.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4(+) T cells.
引用
收藏
页码：470 / 476
页数：7
相关论文
共 63 条
  • [1] CELLULAR LATENCY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS WITH HIGH CD4 LEVELS CAN BE DETECTED BY THE PRESENCE OF PROMOTER-PROXIMAL TRANSCRIPTS
    ADAMS, M
    SHARMEEN, L
    KIMPTON, J
    ROMEO, JM
    GARCIA, JV
    PETERLIN, BM
    GROUDINE, M
    EMERMAN, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) : 3862 - 3866
  • [2] Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    Addo, MM
    Yu, XG
    Rathod, A
    Cohen, D
    Eldridge, RL
    Strick, D
    Johnston, MN
    Corcoran, C
    Wurcel, AG
    Fitzpatrick, CA
    Feeney, ME
    Rodriguez, WR
    Basgoz, N
    Draenert, R
    Stone, DR
    Brander, C
    Goulder, PJR
    Rosenberg, ES
    Altfeld, M
    Walker, BD
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (03) : 2081 - 2092
  • [3] Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
    Allen, TM
    O'Connor, DH
    Jing, PC
    Dzuris, JL
    Mothé, BR
    Vogel, TU
    Dunphy, E
    Liebl, ME
    Emerson, C
    Wilson, N
    Kunstman, KJ
    Wang, XC
    Allison, DB
    Hughes, AL
    Desrosiers, RC
    Altman, JD
    Wolinsky, SM
    Sette, A
    Watkins, DI
    [J]. NATURE, 2000, 407 (6802) : 386 - 390
  • [4] Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences
    Altfeld, M
    Addo, MM
    Shankarappa, R
    Lee, PK
    Allen, TM
    Yu, XG
    Rathod, A
    Harlow, J
    O'Sullivan, K
    Johnston, MN
    Goulder, PJR
    Mullins, JI
    Rosenberg, ES
    Brander, C
    Korber, B
    Walker, BD
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (13) : 7330 - 7340
  • [5] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    Barouch, DH
    Kunstman, J
    Kuroda, MJ
    Schmitz, JE
    Santra, S
    Peyerl, FW
    Krivulka, GR
    Beaudry, K
    Lifton, MA
    Gorgone, DA
    Montefiori, DC
    Lewis, MG
    Wolinsky, SM
    Letvin, NL
    [J]. NATURE, 2002, 415 (6869) : 335 - 339
  • [6] THE SAME INDUCIBLE NUCLEAR PROTEINS REGULATES MITOGEN ACTIVATION OF BOTH THE INTERLEUKIN-2 RECEPTOR-ALPHA GENE AND TYPE-1 HIV
    BOHNLEIN, E
    LOWENTHAL, JW
    SIEKEVITZ, M
    BALLARD, DW
    FRANZA, BR
    GREENE, WC
    [J]. CELL, 1988, 53 (05) : 827 - 836
  • [7] Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
    Borrow, P
    Lewicki, H
    Wei, XP
    Horwitz, MS
    Peffer, N
    Meyers, H
    Nelson, JA
    Gairin, JE
    Hahn, BH
    Oldstone, MBA
    Shaw, GM
    [J]. NATURE MEDICINE, 1997, 3 (02) : 205 - 211
  • [8] HIV vaccine design and the neutralizing antibody problem
    Burton, DR
    Desrosiers, RC
    Doms, RW
    Koff, WC
    Kwong, PD
    Moore, JP
    Nabel, GJ
    Sodroski, J
    Wilson, IA
    Wyatt, RT
    [J]. NATURE IMMUNOLOGY, 2004, 5 (03) : 233 - 236
  • [9] Antibodies, viruses and vaccines
    Burton, DR
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (09) : 706 - 713
  • [10] Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    Chun, TW
    Justement, JS
    Lempicki, RA
    Yang, J
    Dennis, G
    Hallahan, CW
    Sanford, C
    Pandya, P
    Liu, SY
    McLaughlin, M
    Ehler, LA
    Moir, S
    Fauci, AS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) : 1908 - 1913
1234567