Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs

被引：47

作者：

Bailey, J ^{[1
]}

Blankson, JN ^{[1
]}

Wind-Rotolo, M ^{[1
]}

Siliciano, RF ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21204 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1016/j.coi.2004.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4(+) T cells.

引用

页码：470 / 476

页数：7

共 63 条

[21] Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
Goulder, PJR
Phillips, RE
Colbert, RA
McAdam, S
Ogg, G
Nowak, MA
Giangrande, P
Luzzi, G
Morgan, B
Edwards, A
McMichael, AJ
RowlandJones, S
[J]. NATURE MEDICINE, 1997, 3 (02) : 212 - 217
[22] HAN Y, 2004, IN PRESS J VIROL
[23] LENTIVIRUS TAT PROTEINS SPECIFICALLY ASSOCIATE WITH A CELLULAR PROTEIN-KINASE, TAK, THAT HYPERPHOSPHORYLATES THE CARBOXYL-TERMINAL DOMAIN OF THE LARGE SUBUNIT OF RNA-POLYMERASE .2. CANDIDATE FOR A TAT COFACTOR
HERRMANN, CH
RICE, AP
[J]. JOURNAL OF VIROLOGY, 1995, 69 (03) : 1612 - 1620
[24] RAPID TURNOVER OF PLASMA VIRIONS AND CD4 LYMPHOCYTES IN HIV-1 INFECTION
HO, DD
NEUMANN, AU
PERELSON, AS
CHEN, W
LEONARD, JM
MARKOWITZ, M
[J]. NATURE, 1995, 373 (6510) : 123 - 126
[25] Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
Jin, X
Bauer, DE
Tuttleton, SE
Lewin, S
Gettie, A
Blanchard, J
Irwin, CE
Safrit, JT
Mittler, J
Weinberger, L
Kostrikis, LG
Zhang, LQ
Perelson, AS
Ho, DD
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06) : 991 - 998
[26] Viral persistence: HIV's strategies of immune system evasion
Johnson, WE
Desrosiers, RC
[J]. ANNUAL REVIEW OF MEDICINE, 2002, 53 : 499 - 518
[27] CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER
JONES, KA
PETERLIN, BM
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 : 717 - 743
[28] HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
Jordan, A
Bisgrove, D
Verdin, E
[J]. EMBO JOURNAL, 2003, 22 (08) : 1868 - 1877
[29] ANTI-TERMINATION OF TRANSCRIPTION WITHIN THE LONG TERMINAL REPEAT OF HIV-1 BY TAT GENE-PRODUCT
KAO, SY
CALMAN, AF
LUCIW, PA
PETERLIN, BM
[J]. NATURE, 1987, 330 (6147) : 489 - 493
[30] Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition
Koch, M
Pancera, M
Kwong, PD
Kolchinsky, P
Grundner, C
Wang, LP
Hendrickson, WA
Sodroski, J
Wyatt, R
[J]. VIROLOGY, 2003, 313 (02) : 387 - 400

← 1 2 3 4 5 6 7 →