A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake

被引：38

作者：

Cheng, Tangjian ^{[1
]}

Ma, Rujiang ^{[1
]}

Zhang, Yumin ^{[2
,3
]}

Ding, Yuxun ^{[1
]}

Liu, Jinjian ^{[2
,3
]}

Ou, Hanlin ^{[1
]}

An, Yingli ^{[1
]}

Liu, Jianfeng ^{[2
,3
]}

Shi, Linqi ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab Med Chem Biol, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Minist Educ,Inst Polymer Chem,Key Lab Funct Polym, Tianjin 300071, Peoples R China

[2] Chinese Acad Med Sci, Tianjin Key Lab Radiat Med & Mol Nucl Med, Inst Radiat Med, Tianjin 300192, Peoples R China

[3] Peking Union Med Coll, Tianjin 300192, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 81期

基金：

中国国家自然科学基金;

关键词：

ANTICANCER DRUG-DELIVERY; NONVIRAL GENE DELIVERY; POLYMERIC MICELLES; GOLD NANOPARTICLES; PROTEIN ADSORPTION; TUMOR; PH; CHARGE; EFFICACY; THERAPY;

D O I：

10.1039/c5cc05854f

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Based on the protonation/deprotonation of poly(beta-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).

引用

收藏

页码：14985 / 14988

页数：4

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