An expedient total synthesis of cis-(+)-Sertraline from D-phenylglycine

被引：35

作者：

Chandrasekhar, S ^{[1
]}

Reddy, MV ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2000年 / 56卷 / 08期

关键词：

Friedel-Crafts cyclization; serotonin; antidepressants;

D O I：

10.1016/S0040-4020(99)01067-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical total synthesis of cis-(+)-Sertraline is developed involving intramolecular Friedel-Crafts cyclization of an appropriately tailored D-phenylglycine. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1111 / 1114

页数：4

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