Preparation of 124I solutions after thermodistillation of irradiated 124TeO2 targets

被引：48

作者：

Knust, EJ

Dutschka, K

Weinreich, R ^{[1
]}

机构：

[1] Univ Hosp Essen, Dept Nucl Med, D-45122 Essen, Germany

[2] Paul Scherrer Inst, Lab Radio & Environm Chem, CH-5232 Villigen, Switzerland

来源：

APPLIED RADIATION AND ISOTOPES | 2000年 / 52卷 / 02期

关键词：

radionuclide production; I-124; thermodistillation;

D O I：

10.1016/S0969-8043(99)00127-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The 4.15-d radionuclide I-124 is produced via the nuclear reaction Te-124(d, 2n) I-124 by irradiation of 96% enriched (TeO2)-Te-124 with 14 MeV deuterons, followed by thermodistillation. In order to minimise the loss of I-124, the quartz distillation tube was fitted to a stainless steel helix capillary trap directly behind the end of the furnace. Using this device, distillation yields of more than 80% were routinely obtained, and the activity was concentrated in markedly less than 100 mu L solution. The I-124 produced by this method proved to be useful for labelling proteins and IUdR. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：181 / 184

页数：4

共 18 条

[1]

BLASBERG RG, 1996, J NUCL MED S, V37, pP59

[2]

DAGHIGHIAN F, 1993, EUR J NUCL MED, V20, P402

[3]

Firouzbakht Mahmoud L., 1994, Journal of Labelled Compounds and Radiopharmaceuticals, V35, P257

[4] THYROID IMAGING USING POSITRON EMISSION TOMOGRAPHY - A COMPARISON WITH ULTRASOUND IMAGING AND CONVENTIONAL SCINTIGRAPHY IN THYROTOXICOSIS [J].

FLOWER, MA ;

IRVINE, AT ;

OTT, RJ ;

KABIR, F ;

MCCREADY, VR ;

HARMER, CL ;

SHARMA, HL ;

SMITH, AG .

BRITISH JOURNAL OF RADIOLOGY, 1990, 63 (749) :325-330

[5] TOMOGRAPHIC IMAGING OF THE HUMAN THYROID USING I-124 [J].

FREY, P ;

TOWNSEND, D ;

FLATTET, A ;

DEGAUTARD, R ;

WIDGREN, S ;

JEAVONS, A ;

CHRISTIN, A ;

SMITH, A ;

LONG, A ;

DONATH, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 63 (04) :918-927

[6] Radiosynthesis and quality assurance of 5-[124I]Iodo-2′-deoxyuridine for functional PET imaging of cell proliferation [J].

Guenther, I ;

Wyer, L ;

Knust, EJ ;

Finn, RD ;

Koziorowski, J ;

Weinreich, R .

NUCLEAR MEDICINE AND BIOLOGY, 1998, 25 (04) :359-365

[7] RADIOPHARMACEUTICAL PREPARATION OF 3-123-I-ALPHA-METHYLTYROSINE FOR NUCLEAR-MEDICAL APPLICATIONS [J].

KNUST, EJ ;

DUTSCHKA, K ;

MACHULLA, HJ .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS, 1990, 144 (02) :107-113

[8] A cryotrap as flow reactor for synthesis of 211At labelled compounds [J].

Koziorowski, J ;

Lebeda, O ;

Weinreich, R .

APPLIED RADIATION AND ISOTOPES, 1999, 50 (03) :527-529

[9] PRODUCTION OF I-124 [J].

LAMBRECHT, RM ;

SAJJAD, M ;

QURESHI, MA ;

ALYANBAWI, SJ .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY-LETTERS, 1988, 127 (02) :143-150

[10]

LANGEN KJ, 1990, J NUCL MED, V31, P281

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