Does the mechanism of protection from falciparum malaria by red cell genetic disorders involve a switch to a balanced T(H)1/T(H)2 cytokine production mode?

被引:14
作者
Bayoumi, RAL
机构
[1] Biochemistry Department, Fac. of Medicine and Health Sciences, United Arab Emirates University, 17666 Al-Ain, Post Box
关键词
D O I
10.1016/S0306-9877(97)90017-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The mechanism of protection from falciparum malaria by red cell genetic disorders still remains controversial. Decreased survival of parasites in variant red cells has previously been proposed. However, in vitro experiments were not conclusive and do not seem sufficient to explain the substantial degree of in vivo protection afforded to red cell genetic trait carriers. Evidence has recently been accumulating in favour of enhancement of the host immune response by these genetic traits. Malaria-infected variant red cells undergo modifications to their antigenicity which lead to accelerated and selective removal of early blood-stage parasites by splenic macrophages, resulting in fewer parasites reaching schizogony. Consequently there will be alterations in antigen processing, presentation and recognition which could explain the differences observed in T-cell responses between trait carriers and normal individuals. It is suggested that exposure to a lower dose of early parasite-stage antigens rather than the exoantigens of late mature schizonts could lead during primary and subsequent secondary infections to differentiation of T-helper cells into balanced T(H)1/T(H)2 subsets that promote protection, reversing the susceptibility to the fatal complications of falciparum malaria.
引用
收藏
页码:11 / 17
页数:7
相关论文
共 66 条
  • [51] IMPAIRMENT OF MACROPHAGE FUNCTIONS AFTER INGESTION OF PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES OR ISOLATED MALARIAL PIGMENT
    SCHWARZER, E
    TURRINI, F
    ULLIERS, D
    GIRIBALDI, G
    GINSBURG, H
    ARESE, P
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) : 1033 - 1041
  • [52] IMMUNOREGULATION OF CUTANEOUS LEISHMANIASIS - T-CELL LINES THAT TRANSFER PROTECTIVE IMMUNITY OR EXACERBATION BELONG TO DIFFERENT T-HELPER SUBSETS AND RESPOND TO DISTINCT PARASITE ANTIGENS
    SCOTT, P
    NATOVITZ, P
    COFFMAN, RL
    PEARCE, E
    SHER, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (05) : 1675 - 1684
  • [53] TRANSGENIC AND MUTANT ANIMAL-MODELS TO STUDY MECHANISMS OF PROTECTION OF RED-CELL GENETIC-DEFECTS AGAINST MALARIA
    SHEAR, HL
    [J]. EXPERIENTIA, 1993, 49 (01): : 37 - 42
  • [54] SHEAR HL, 1993, BLOOD, V81, P222
  • [55] STEVENSON MM, 1993, CLIN EXP IMMUNOL, V92, P77, DOI 10.1111/j.1365-2249.1993.tb05951.x
  • [56] MALARIA EXOANTIGENS INDUCE TNF, ARE TOXIC AND ARE BLOCKED BY T-INDEPENDENT ANTIBODY
    TAVERNE, J
    BATE, CAW
    PLAYFAIR, JHL
    [J]. IMMUNOLOGY LETTERS, 1990, 25 (1-3) : 207 - 212
  • [57] PROTECTIVE CD4+ T-CELL LINES RAISED AGAINST PLASMODIUM-CHABAUDI SHOW CHARACTERISTICS OF EITHER TH1 OR TH2 CELLS
    TAYLORROBINSON, AW
    PHILLIPS, RS
    [J]. PARASITE IMMUNOLOGY, 1993, 15 (06) : 301 - 310
  • [58] REDUCED CELLULAR IMMUNE REACTIVITY IN HEALTHY-INDIVIDUALS DURING THE MALARIA TRANSMISSION SEASON
    THEANDER, TG
    HVIID, L
    ABUZEID, YA
    ABDULHADI, NH
    SAEED, BO
    JAKOBSEN, PH
    REIMERT, CM
    JEPSEN, S
    BAYOUMI, RAL
    JENSEN, JB
    [J]. IMMUNOLOGY LETTERS, 1990, 25 (1-3) : 237 - 242
  • [59] Theander Thor G., 1993, Immunology and Infectious Diseases (Oxford), V3, P97
  • [60] THE INVOLVEMENT OF HEMOZOIN TOXICITY IN DEPRESSION OF CELLULAR-IMMUNITY
    TURRINI, F
    SCHWARZER, E
    ARESE, P
    [J]. PARASITOLOGY TODAY, 1993, 9 (08): : 297 - 300