A New Gq-Initiated MAPK Signaling Pathway in the Heart

被引：31

作者：

Gutkind, J. Silvio ^{[1
]}

Offermanns, Stefan ^{[2
,3
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, NIH, Bethesda, MD 20892 USA

[2] Univ Heidelberg, Inst Pharmacol, D-69120 Heidelberg, Germany

[3] Max Planck Inst Heart & Lung Res, Dept Pharmacol, D-61231 Bad Nauheim, Germany

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 02期

关键词：

CARDIAC-HYPERTROPHY; MYOCARDIAL HYPERTROPHY;

D O I：

10.1016/j.devcel.2009.01.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Pathological cardiac hypertrophy involves auto/paracrine mediators acting through G(q/11)-coupled receptors. A novel signaling route stimulated by beta gamma-subunits of G(q/11) results in the autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby activating hypertrophic gene programs.

引用

收藏

页码：163 / 164

页数：2

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