Furocoumarins from Angelica dahurica with hepatoprotective activity on tacrine-induced cytotoxicity in Hep G2 cells

被引：72

作者：

Oh, H

Lee, HS

Kim, T

Chai, KY

Chung, HT

Kwon, TO

Jun, JY

Jeong, OS

Kim, YC

Yun, YG ^{[1
]}

机构：

[1] Wonkwang Univ, Med Resources Res Ctr, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Grad Sch Oriental Med, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, MRRC, Iksan 570749, Chonbuk, South Korea

[4] Wonkwang Univ, Coll Pharm, Iksan 570749, Chonbuk, South Korea

来源：

PLANTA MEDICA | 2002年 / 68卷 / 05期

关键词：

D O I：

10.1055/s-2002-32075

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (+/-)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC50 values of 36.6+/-0.98 and 47.9+/-4.6 muM, respectively. Compounds 3 and 4 showed moderate activities with EC50 values of 112.7+/-5.35 and 286.7+/-6.36 muM, respectively. Silybin as a positive control showed the EC50 value with 69.0+/-3.4 muM. Comparison of hepatoprotective activities for six furocournarins 1-6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.

引用

页码：463 / 464

页数：2

共 12 条

[1]

Noninterference of cytochrome P4501A2 in the cytotoxicity of tacrine using genetically engineered V79 Chinese hamster cells for stable expression of the human or rat isoform and two human hepatocyte cell lines [J].