Suitable entry to a 10-membered ring with eleutheside functionality through Nozaki-Hiyama condensation

被引：25

作者：

Sandoval, C ^{[1
]}

Redero, E ^{[1
]}

Mateos-Timoneda, MA ^{[1
]}

Bermejo, FA ^{[1
]}

机构：

[1] Univ Salamanca, Dept Quim Organ, E-37008 Salamanca, Spain

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 37期

关键词：

anticancer agents; antimitotic; eleuthesides; sarcodictyns; eleutherobin; Nozaki-Hiyama condensation;

D O I：

10.1016/S0040-4039(02)01475-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Access to a medium-sized unit of 15-seco-eleutheside analog 19 has been opened through the NiCl2/CrCl2-mediated intramolecular condensation of iodoaldehyde 8 with excellent yields. Transformation of the phenylcyclononanol 15 into the tetracyclic analog 19 was achieved in a four-step sequence with 65%, overall yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6521 / 6524

页数：4

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