Principles of connectivity among morphologically defined cell types in adult neocortex

被引：553

作者：

Jiang, Xiaolong ^{[1
]}

Shen, Shan ^{[1
]}

Cadwell, Cathryn R. ^{[1
]}

Berens, Philipp ^{[1
,2
,3
,4
,5
]}

Sinz, Fabian ^{[1
]}

Ecker, Alexander S. ^{[1
,2
,4
,5
,6
]}

Patel, Saumil ^{[1
]}

Tolias, Andreas S. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[2] Bernstein Ctr Computat Neurosci, Tubingen, Germany

[3] Univ Tubingen, Inst Ophthalm Res, Tubingen, Germany

[4] Univ Tubingen, Werner Reichardt Ctr Integrat Neurosci, Tubingen, Germany

[5] Univ Tubingen, Inst Theoret Phys, Tubingen, Germany

[6] Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany

来源：

SCIENCE | 2015年 / 350卷 / 6264期

关键词：

GABAERGIC INTERNEURONS; PYRAMIDAL NEURONS; VISUAL-CORTEX; RAT NEOCORTEX; INHIBITORY INTERNEURONS; SOMATOSENSORY CORTEX; CORTICAL-NEURONS; CEREBRAL-CORTEX; INTEGRATION; RECEPTORS;

D O I：

10.1126/science.aac9462

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Since the work of Ramon y Cajal in the late 19th and early 20th centuries, neuroscientists have speculated that a complete understanding of neuronal cell types and their connections is key to explaining complex brain functions. However, a complete census of the constituent cell types and their wiring diagram in mature neocortex remains elusive. By combining octuple whole-cell recordings with an optimized avidin-biotin-peroxidase staining technique, we carried out a morphological and electrophysiological census of neuronal types in layers 1, 2/3, and 5 of mature neocortex and mapped the connectivity between more than 11,000 pairs of identified neurons. We categorized 15 types of interneurons, and each exhibited a characteristic pattern of connectivity with other interneuron types and pyramidal cells. The essential connectivity structure of the neocortical microcircuit could be captured by only a few connectivity motifs.

引用

页数：11

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