Paused Pol II captures enhancer activity and acts as a potent insulator

被引：19

作者：

Core, Leighton J. ^{[1
]}

Lis, John T. ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

GENES & DEVELOPMENT | 2009年 / 23卷 / 14期

关键词：

Hox; Pol II stalling; insulator; NELF; DSIF; long range; RNA-POLYMERASE-II; DROSOPHILA-BITHORAX COMPLEX; GAGA-FACTOR; PROMOTER ARCHITECTURE; BLOCKING ACTIVITY; GENE-EXPRESSION; CORE PROMOTERS; FAB-7; BOUNDARY; ABDOMINAL-A; TRANSCRIPTION;

D O I：

10.1101/gad.1827709

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enhancers act over many kilobase pairs to activate target promoters, but their activity is constrained by insulator elements that prevent indiscriminate activation of nearby genes. In the July 1, 2009, issue of Genes & Development, Chopra and colleagues (pp. 1505-1509) report that promoters containing a stalled Pol II are activated by enhancers, but these promoters also serve as insulators that block enhancers from reaching more distal genes. This new class of insulators provide critical clues to regulatory mechanisms.

引用

页码：1606 / 1612

页数：7

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