Breaking barriers to transcription elongation

被引：387

作者：

Saunders, Abbie ^{[1
]}

Core, Leighton J. ^{[1
]}

Lis, John T. ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1981

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many of these proteins regulate specific genes by targeting upstream promoter regions, whereas a smaller but mechanistically diverse set of factors functions at most genes during RNA polymerase II (Pol II) elongation. These elongation factors can affect mRNA production at particular stages and in different ways during transcription. Some factors act directly on Pol II, whereas others manipulate the chromatin environment.

引用

页码：557 / 567

页数：11

共 151 条

[1] Drosophila Paf1 modulates chromatin structure at actively transcribed genes [J].

Adelman, K ;

Wei, WX ;

Ardehali, MB ;

Werner, J ;

Zhu, B ;

Reinberg, D ;

Lis, JT .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (01) :250-260

[2] Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS [J].

Adelman, K ;

Marr, MT ;

Werner, J ;

Saunders, A ;

Ni, ZY ;

Andrulis, ED ;

Lis, JT .

MOLECULAR CELL, 2005, 17 (01) :103-112

[3] Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PH05 and PH08 genes [J].

Adkins, MW ;

Howar, SR ;

Tyler, JK .

MOLECULAR CELL, 2004, 14 (05) :657-666

[4] High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo:: roles in promoter proximal pausing and transcription elongation [J].

Andrulis, ED ;

Guzmán, E ;

Döring, P ;

Werner, J ;

Lis, JT .

GENES & DEVELOPMENT, 2000, 14 (20) :2635-2649

[5] The Drosophila BRM complex facilitates global transcription by RNA polymerase II [J].

Armstrong, JA ;

Papoulas, O ;

Daubresse, G ;

Sperling, AS ;

Lis, JT ;

Scott, MP ;

Tamkun, JW .

EMBO JOURNAL, 2002, 21 (19) :5245-5254

[6] A new paradigm in eukaryotic biology: HIV tat and the control of transcriptional elongation [J].

Barboric, M ;

Peterlin, BM .

PLOS BIOLOGY, 2005, 3 (02) :200-203

[7] FACT facilitates transcription-dependent nucleosome alteration [J].

Belotserkovskaya, R ;

Oh, S ;

Bondarenko, VA ;

Orphanides, G ;

Studitsky, VM ;

Reinberg, D .

SCIENCE, 2003, 301 (5636) :1090-1093

[8] Removal of promoter nucleosomes by disassembly rather than sliding in vivo [J].

Boeger, H ;

Griesenbeck, J ;

Strattan, JS ;

Kornberg, RD .

MOLECULAR CELL, 2004, 14 (05) :667-673

[9] Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock [J].

Boehm, AK ;

Saunders, A ;

Werner, J ;

Lis, JT .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (21) :7628-7637

[10] Evidence that Spt6p controls chromatin structure by a direct interaction with histones [J].

Bortvin, A ;

Winston, F .

SCIENCE, 1996, 272 (5267) :1473-1476

← 1 2 3 4 5 6 7 8 9 10 →