Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation:: a new class of potential antioxidant agents

被引：159

作者：

Stefani, Helio A. ^{[1
]}

Oliveira, Carlindo B.

Almeida, Roberta B.

Pereira, Claudio M. P.

Braga, Rodolpho C.

Cella, Rodrigo

Borges, Vanessa C.

Savegnago, Lucielli

Nogueira, Cristina W.

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo, Dept Biofis, Sao Paulo, SP, Brazil

[3] Univ Sao Paulo, Inst Quim, Sao Paulo, SP, Brazil

[4] Univ Fed Santa Maria, Dept Quim, Santa Maria, RS, Brazil

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

Biginelli; dihydropyrimidinones; antioxidant; reactive oxygen species; pharmacological;

D O I：

10.1016/j.ejmech.2006.01.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH4Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：513 / 518

页数：6

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