Antiviral activity of substituted homoisoflavonoids on enteroviruses

被引：84

作者：

Tait, Sabrina

Salvati, Anna Laura

Desideri, Nicoletta

Fiore, Lucia

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Dept Pharmaceut Studies, I-00185 Rome, Italy

来源：

ANTIVIRAL RESEARCH | 2006年 / 72卷 / 03期

关键词：

antivirals; homoisoflavonoids; enteroviruses;

D O I：

10.1016/j.antiviral.2006.07.003

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The antiviral activity of homoisoflavonoids, a class of flavonoids, was determined in vitro against a large panel of enteroviruses. The inhibition of viral replication was monitored on BGM (Buffalo Green Monkey) cells, and the concentration required for 50% inhibition (IC50), as well as the selectivity index (SI) were determined. None of the substances were effective against Sabin type 1 poliovirus (PV1), but most of them showed a low cytotoxicity and a marked antiviral activity against Coxsackie virus B1, B3, B4, A9 and echovirus 30. (c) 2006 Elsevier B.V. All rights reserved.

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页码：252 / 255

页数：4

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