Association study of the 5-hydroxytryptamine6 receptor gene in Alzheimer's disease

被引：19

作者：

Orlacchio, A

Kawarai, T

Paciotti, E

Stefani, A

Orlacchio, A

Sorbi, S

St George-Hyslop, PH

Bernardi, G

机构：

[1] IRCCS, Neurogenet Lab, I-00179 Rome, Italy

[2] Univ Roma Tor Vergata, Osped S Eugenio Neurol, Dipartimento Neurosci, I-00144 Rome, Italy

[3] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada

[4] Toronto Hosp, Dept Med, Toronto, ON M5T 2S8, Canada

[5] Univ Perugia, Dipartiemnto Sci Biochim & Biotecnol Mol, I-06126 Perugia, Italy

[6] Univ Florence, Dipartimento Sci Neurol & Psichiat, I-50134 Florence, Italy

来源：

NEUROSCIENCE LETTERS | 2002年 / 325卷 / 01期

关键词：

Alzheimer's disease; single nucleotide polymorphism; 5-hydroxytryptamine(6) receptor gene;

D O I：

10.1016/S0304-3940(02)00221-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonergic (5-hydroxytryptamine; 5-HT) transmission has been implicated in the pathogenesis of Alzheimer's disease (AD). A coding single nucleotide polymorphism 267 (C/T) in the 5-HT6 receptor gene was previously reported as a susceptibility factor for AD. An extensive replication study was performed using our data set including sporadic and familial cases. No significant association between the 5-HT6 receptor gene and AD was obtained with or without the stratification of apolipoprotein E epsilon4 status. Our result suggests that the 267C allele of the 5-HT6 receptor gene may not be a genetic risk factor for AD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

共 20 条

[1] Evidence for genetic linkage of Alzheimer's disease to chromosome 10q [J].

Bertram, L ;

Blacker, D ;

Mullin, K ;

Keeney, D ;

Jones, J ;

Basu, S ;

Yhu, S ;

McInnis, MG ;

Go, RCP ;

Vekrellis, K ;

Selkoe, DJ ;

Saunders, AJ ;

Tanzi, RE .

SCIENCE, 2000, 290 (5500) :2302-+

[2] The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus [J].

Dawson, LA ;

Nguyen, HQ ;

Li, P .

NEUROPSYCHOPHARMACOLOGY, 2001, 25 (05) :662-668

[3] Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees [J].

Ertekin-Taner, N ;

Graff-Radford, N ;

Younkin, LH ;

Eckman, C ;

Baker, M ;

Adamson, J ;

Ronald, J ;

Blangero, J ;

Hutton, M ;

Younkin, SG .

SCIENCE, 2000, 290 (5500) :2303-+

[4] Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis [J].

Farrer, LA ;

Cupples, LA ;

Haines, JL ;

Hyman, B ;

Kukull, WA ;

Mayeux, R ;

Myers, RH ;

PericakVance, MA ;

Risch, N ;

vanDuijn, CM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16) :1349-1356

[5] Family-based tests of association in the presence of linkage [J].

Lake, SL ;

Blacker, D ;

Laird, NM .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (06) :1515-1525

[6] Susceptibility locus for Alzheimer's disease on chromosome 10 [J].

Myers, A ;

Holmans, P ;

Marshall, H ;

Kwon, J ;

Meyer, D ;

Ramic, D ;

Shears, S ;

Booth, J ;

DeVrieze, FW ;

Crook, R ;

Hamshere, M ;

Abraham, R ;

Tunstall, N ;

Rice, F ;

Carty, S ;

Lillystone, S ;

Kehoe, P ;

Rudrasingham, V ;

Jones, L ;

Lovestone, S ;

Perez-Tur, J ;

Williams, J ;

Owen, MJ ;

Hardy, J ;

Goate, AM .

SCIENCE, 2000, 290 (5500) :2304-+

[7] Absence of linkage between familial amyotrophic lateral sclerosis and copper chaperone for the superoxide dismutase gene locus in two Italian pedigrees [J].

Orlacchio, A ;

Kawarai, T ;

Massaro, AM ;

St George-Hyslop, PH ;

Sorbi, S .

NEUROSCIENCE LETTERS, 2000, 285 (02) :83-86

[8]

PERICAKVANCE MA, 1991, AM J HUM GENET, V48, P1034

[9] Lack of replication of association findings in complex disease:: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease [J].

Prince, JA ;

Feuk, L ;

Sawyer, SL ;

Gottfries, J ;

Ricksten, A ;

Nägga, K ;

Bogdanovic, N ;

Blennow, K ;

Brookes, AJ .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2001, 9 (06) :437-444

[10] Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity [J].

Rogaeva, E ;

Premkumar, S ;

Song, YQ ;

Sorbi, S ;

Brindle, N ;

Paterson, A ;

Duara, R ;

Levesque, G ;

Yu, G ;

Nishimura, M ;

Ikeda, M ;

O'Toole, C ;

Kawarai, T ;

Jorge, R ;

Vilarino, D ;

Bruni, AC ;

Farrer, LA ;

St George-Hyslop, PH .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (07) :614-618

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