Potassium secretion and the regulation of distal nephron K channels

被引:75
作者
Palmer, LG [1 ]
机构
[1] Cornell Univ, Weill Med Coll, Dept Physiol & Biophys, New York, NY 10021 USA
关键词
ROMK channels; potassium adaptation; mineralocorticoids; kaliuretic hormones;
D O I
10.1152/ajprenal.1999.277.6.F821
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
K-selective channels in the luminal membranes of distal nephron segments form a key pathway for the secretion of K ions into the urine. This process is important to the control of K balance, particularly under conditions of normal or high K intake. This brief review will cover three issues: 1) the identification of apical K channels, 2) the role of these channels in the maintenance of K homeostasis, and 3) the role of aldosterone in this regulatory process. The large amount of literature on renal K transport has been elegantly summarized in a recent review in this journal [G. Giebisch. Am. J. Physiol. 274 (Renal Physiol. 43): F817-F833, 1998]. Here I will focus on a few prominent unsolved problems.
引用
收藏
页码:F821 / F825
页数:5
相关论文
共 61 条
[51]   Regulation of the ROMK channel: interaction of the ROMK with associate proteins [J].
Wang, WH .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1999, 277 (06) :F826-F831
[52]   REGULATION OF SMALL-CONDUCTANCE K+ CHANNEL IN APICAL MEMBRANE OF RAT CORTICAL COLLECTING TUBULE [J].
WANG, WH ;
SCHWAB, A ;
GIEBISCH, G .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (03) :F494-F502
[53]   2 TYPES OF K+ CHANNEL IN THICK ASCENDING LIMB OF RAT-KIDNEY [J].
WANG, WH .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1994, 267 (04) :F599-F605
[54]   Renal K+ channels: Structure and function [J].
Wang, WH ;
Hebert, SC ;
Giebisch, G .
ANNUAL REVIEW OF PHYSIOLOGY, 1997, 59 :413-436
[55]   DIETARY MODULATION OF ACTIVE POTASSIUM SECRETION IN THE CORTICAL COLLECTING TUBULE OF ADRENALECTOMIZED RABBITS [J].
WINGO, CS ;
SELDIN, DW ;
KOKKO, JP ;
JACOBSON, HR .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (03) :579-586
[56]  
Wright FS, 1992, KIDNEY PHYSL PATHOPH, P2209
[57]   Localization of the ROMK protein on apical membranes of rat kidney nephron segments [J].
Xu, JZ ;
Hall, AE ;
Peterson, LN ;
Bienkowski, MJ ;
Eessalu, TE ;
Hebert, SC .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1997, 273 (05) :F739-F748
[58]   Phosphorylation of the ATP-sensitive, inwardly rectifying K+ channel, ROMK, by cyclic AMP-dependent protein kinase [J].
Xu, ZC ;
Yang, YH ;
Hebert, SC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (16) :9313-9319
[59]   INTERRELATED EFFECTS OF ALDOSTERONE AND PLASMA POTASSIUM ON POTASSIUM EXCRETION [J].
YOUNG, DB ;
PAULSEN, AW .
AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 244 (01) :F28-F34
[60]   PRIMARY STRUCTURE AND FUNCTIONAL-PROPERTIES OF AN EPITHELIAL K-CHANNEL [J].
ZHOU, H ;
TATE, SS ;
PALMER, LG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (03) :C809-C824