AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

被引：694

作者：

Hardie, D. Grahame ^{[1
]}

Schaffer, Bethany E. ^{[2
,3
]}

Brunet, Anne ^{[2
,3
]}

机构：

[1] Univ Dundee, Sch Life Sci, Div Cell Signalling & Immunol, Dow St, Dundee DD1 5EH, Scotland

[2] Stanford Univ, Dept Genet, 300 Pasteur Dr, Stanford, CA 94305 USA

[3] Stanford Univ, Canc Biol Program, 300 Pasteur Dr, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 03期

基金：

英国惠康基金;

关键词：

ACTIVATED PROTEIN-KINASE; CHEMICAL GENETIC SCREEN; HMG-COA REDUCTASE; STRUCTURAL BASIS; SKELETAL-MUSCLE; IDENTIFICATION; SUBSTRATE; NETWORK; PHOSPHORYLATION; MECHANISM;

D O I：

10.1016/j.tcb.2015.10.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide-dependent mechanism that activates AMPK when cellular energy status is compromised, as well as other, noncanonical activation mechanisms. Once activated, AMPK acts to restore energy homeostasis by promoting catabolic pathways, resulting in ATP generation, and inhibiting anabolic pathways that consume ATP. We also review the various hypothesis-driven and unbiased approaches that have been used to identify AMPK substrates and have revealed substrates involved in both metabolic and non-metabolic processes. We particularly focus on methods for identifying the AMPK target recognition motif and how it can be used to predict new substrates.

引用

页码：190 / 201

页数：12

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