Cell-cell signalling: Frog frizbees

被引:17
作者
Zorn, AM
机构
关键词
D O I
10.1016/S0960-9822(06)00248-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent discovery that Frizzled proteins are receptors for Wnts has been quickly followed by the identification of a secreted protein, Frzb, that is related to Frizzled, expressed by the Spemann organizer in frog embryos and can bind to and antagonize Wnt developmental signalling molecules.
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页码:R501 / R504
页数:4
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共 18 条
[1]   A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].
Bhanot, P ;
Brink, M ;
Samos, CH ;
Hsieh, JC ;
Wang, YS ;
Macke, JP ;
Andrew, D ;
Nathans, J ;
Nusse, R .
NATURE, 1996, 382 (6588) :225-230
[2]   INTERACTIONS BETWEEN XWNT-8 AND SPEMANN ORGANIZER SIGNALING PATHWAYS GENERATE DORSOVENTRAL PATTERN IN THE EMBRYONIC MESODERM OF XENOPUS [J].
CHRISTIAN, JL ;
MOON, RT .
GENES & DEVELOPMENT, 1993, 7 (01) :13-28
[3]   A common plan for dorsoventral patterning in Bilateria [J].
DeRobertis, EM ;
Sasai, Y .
NATURE, 1996, 380 (6569) :37-40
[4]   Embryonic patterning: To BMP or not to BMP, that is the question [J].
Graff, JM .
CELL, 1997, 89 (02) :171-174
[5]   Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis [J].
Hoang, B ;
Moos, M ;
Vukicevic, S ;
Luyten, FP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) :26131-26137
[6]   Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos [J].
Hoppler, S ;
Brown, JD ;
Moon, RT .
GENES & DEVELOPMENT, 1996, 10 (21) :2805-2817
[7]   The vertebrate organizer: Structure and molecules [J].
Lemaire, P ;
Kodjabachian, L .
TRENDS IN GENETICS, 1996, 12 (12) :525-531
[8]   Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer [J].
Leyns, L ;
Bouwmeester, T ;
Kim, SH ;
Piccolo, S ;
DeRobertis, EM .
CELL, 1997, 88 (06) :747-756
[9]   WNTs modulate cell fate and behavior during vertebrate development [J].
Moon, RT ;
Brown, JD ;
Torres, M .
TRENDS IN GENETICS, 1997, 13 (04) :157-162
[10]   A versatile transcriptional effector of wingless signaling [J].
Nusse, R .
CELL, 1997, 89 (03) :321-323