Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer

被引：626

作者：

Leyns, L ^{[1
]}

Bouwmeester, T ^{[1
]}

Kim, SH ^{[1
]}

Piccolo, S ^{[1
]}

DeRobertis, EM ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,DEPT BIOL CHEM,LOS ANGELES,CA 90095

来源：

CELL | 1997年 / 88卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(00)81921-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.

引用

页码：747 / 756

页数：10

共 46 条

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