A direct catalytic aldol route to protected β-hydroxy-α-amino acids

被引：14

作者：

Willis, MC ^{[1
]}

Piccio, VJD ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

SYNLETT | 2002年 / 10期

关键词：

catalysis; amino acids; aldol reaction; Lewis acid;

D O I：

10.1055/s-2002-34241

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of triethylamine, magnesium(II) perchlorate and bipyridine generates a catalyst system for the efficient combination of ethyl isothiocyanatoacetate and a range of aromatic aldehydes. The products of these reactions are synthetically valuable protected beta-hydroxy alpha-amino acids.

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收藏

页码：1625 / 1628

页数：4

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