Copper-Catalyzed C-C Bond Formation through C-H Functionalization: Synthesis of Multisubstituted Indoles from N-Aryl Enaminones

被引：315

作者：

Bernini, Roberta ^{[2
,3
]}

Fabrizi, Giancarlo ^{[1
]}

Sferrazza, Alessio ^{[1
]}

Cacchi, Sandro ^{[1
]}

机构：

[1] Univ Rome, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy

[2] Univ Tuscia, Dipartimento ABAC, Viterbo, Italy

[3] Consorzio Univ La Chim Ambiente, Viterbo, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 43期

关键词：

C-C coupling; copper; heterogeneous catalysis; indoles; synthesis design; CONJUGATE REDUCTION; DIRECT ARYLATIONS; ACTIVATION; AMINATION; CYCLIZATION; ANALOGS; ESTERS;

D O I：

10.1002/anie.200902440

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines. © 2009 Wiley-VCH Verlag.

引用

收藏

页码：8078 / 8081

页数：4

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