Probing Surface Charge Fluctuations with Solid-State Nanopores

被引：166

作者：

Hoogerheide, David P. ^{[1
]}

Garaj, Slaven ^{[1
]}

Golovchenko, Jene A. ^{[1
]}

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

来源：

PHYSICAL REVIEW LETTERS | 2009年 / 102卷 / 25期

关键词：

NOISE; TRANSPORT; MOLECULES; CHANNEL; DNA;

D O I：

10.1103/PhysRevLett.102.256804

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We identify a contribution to the ionic current noise spectrum in solid-state nanopores that exceeds all other noise sources in the frequency band 0.1-10 kHz. Experimental studies of the dependence of this excess noise on pH and electrolyte concentration indicate that the noise arises from surface charge fluctuations. A quantitative model based on surface functional group protonization predicts the observed behaviors and allows us to locally measure protonization reaction rates. This noise can be minimized by operating the nanopore at a deliberately chosen pH.

引用

页数：4

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