Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2

被引：57

作者：

Hua Jiang ^{[1
]}

Chang-Sheng Deng ^{[1
]}

Ming Zhang ^{[1
]}

Jian Xia ^{[1
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Gastroenterol, Wuhan 430071, Hubei, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 24期

关键词：

colitis; curcumin; cyclooxygenase-2; PGE(2); TNBS acid;

D O I：

10.3748/wjg.v12.i24.3848

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To explore the possible mechanisms of curcumin in rat colitis induced by trinitrobenzene sulfonic (TNBS) acid. METHODS: Rats with TNBS acid-induced colitis were treated with curcumin (30 mg/kg or 60 mg/kg per day ip). Changes of body weight and histological scores as well as survival rate were evaluated. Leukocyte infiltration was detected by myeloperoxidase (MPO) activity assay. The expression of cyclooxygenase-2 (COX-2) was detected by RT-PCR and Western blot. Inflammation cytokines were determined by RT-PCR. Local concentration of prostaglandin E-2 (PGE(2)) in colon mucosa was determined by ELISA. RESULTS: Curcumin improved survival rate and histological image, decreased the macroscopic scores and MPO activity. Also curcumin reduced the expression of COX-2 and inflammation cytokines. In addition, treatment with curcumin increased the PGE(2) level. CONCLUSION: Curcumin has therapeutic effects on TNBS acid-induced colitis, the mechanisms seem to be related to COX-2 inhibition and PGE(2) improvement. (C) 2006 The WIG Press. All rights reserved.

引用

页码：3848 / 3853

页数：6

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