Non-coding RNAs in Polycomb/Trithorax regulation

被引:49
作者
Hekimoglu, Betuel [1 ]
Ringrose, Leonie [1 ]
机构
[1] Inst Mol Biotechnol GmbH, IMBA, A-1030 Vienna, Austria
基金
奥地利科学基金会;
关键词
Polycomb; Trithorax; PRE/TRE; epigenetic; non-coding RNA; chromatin; POLYCOMB GROUP PROTEINS; RESPONSE ELEMENTS; EPIGENETIC INHERITANCE; BITHORAX COMPLEX; GENE-EXPRESSION; HETEROCHROMATIN FORMATION; DEVELOPMENTAL REGULATORS; DNA ELIMINATION; HISTONE H3; CHROMATIN;
D O I
10.4161/rna.6.2.8178
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Polycomb (PcG) and Trithorax (TrxG) proteins are epigenetic regulators that maintain correct expression patterns of several hundred developmentally important genes by binding to DNA regulatory elements called Polycomb/Trithorax Response Elements (PRE/TREs). Many PRE/TREs are transcribed into long non-coding RNAs. Furthermore, many PcG and TrxG proteins bind to RNA, and recent evidence suggests that these RNA interactions are essential for targeting both groups of proteins to specific sites, and modulating their effects on gene expression. We discuss current evidence for the molecular mechanisms by which non-coding RNAs may recruit PcG and TrxG proteins, switch gene expression states, and maintain epigenetic memory.
引用
收藏
页码:129 / 137
页数:9
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