NMDA receptor pathways as drug targets

被引：401

作者：

Kemp, JA

McKernan, RM

机构：

[1] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Merck Res Labs, Harlow CM20 2QR, Essex, England

[2] EVOTEC Neurosci GmbH, D-22525 Hamburg, Germany

来源：

NATURE NEUROSCIENCE | 2002年 / 5卷 / Suppl 11期

关键词：

D O I：

10.1038/nn936

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Since the mid 1980s, there has been a great deal of enthusiasm within both academia and industry about the therapeutic potential of drugs targeting the NMDA subtype of glutamate receptors. That early promise is just beginning to translate into approvable drugs. Here we review the reasons for this slow progress and critically assess the future prospects for drugs that act on NMDA receptor pathways, including potential treatments for some major disorders such as stroke and Alzheimer's disease, for which effective therapies are still lacking.

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页码：1039 / 1042

页数：4

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