The fabrication and characterization of dicalcium phosphate dihydrate-modified magnetic nanoparticles and their performance in hyperthermia processes in vitro

被引：41

作者：

Hou, Chun-han ^{[1
,2
,3
]}

Chen, Ching-wei ^{[4
]}

Hou, Sheng-mou ^{[1
,2
,5
]}

Li, Yu-ting ^{[1
,2
]}

Lin, Feng-huei ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Coll Engn, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Orthopaed Surg, Yun Lin Branch, Yun Lin Cty, Taiwan

[4] Natl Taipei Univ Technol, Inst Mat Sci & Engn, Taipei, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Orthopaed Surg, Taipei, Taiwan

来源：

BIOMATERIALS | 2009年 / 30卷 / 27期

关键词：

Brushite; Calcium phosphate; Nanoparticle; Nanocomposite; Magnetism; In vitro test; CALCIUM-PHOSPHATE; CANCER; CEMENT; IRON;

D O I：

10.1016/j.biomaterials.2009.05.018

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Many different types of magnetic particles have been developed for the purpose of hyperthermia cancer therapy. In this study, a magnetic nanoparticle based on dicalcium phosphate dihydrate (DCPD) was formed by co-precipitation method. Addition of different concentrations of ferrous chloride to DCPD can alter its material properties. Various physical, chemical and magnetic tests of the magnetic DCPD nanoparticles (mDCPD) were performed, including X-ray diffraction (XRD), inductively coupled plasma-optical emission spectrometer (ICP-OES), superconducting quantum interference device (SQUID), and transmission electron microscopy (TEM). The heating efficiency of mDCPD in alternating magnetic field was proved to be suitable for hyperthermia. The results of cytotoxicity tests (WST-1 and LDH assay) showed no harmful effect. The mDCPD showed relative cancer-killing ability without damaging normal cells in vitro. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4700 / 4707

页数：8

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