Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector

被引：230

作者：

Hinnebusch, BJ ^{[1
]}

Rudolph, AE

Cherepanov, P

Dixon, JE

Schwan, TG

Forsberg, Å

机构：

[1] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA

[2] Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

[3] Umea Univ, Dept Mol Biol, S-90187 Umea, Sweden

[4] Swedish Def Res Agcy, Dept Med Countermeasures, S-90182 Umea, Sweden

来源：

SCIENCE | 2002年 / 296卷 / 5568期

关键词：

D O I：

10.1126/science.1069972

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transmission by flea bite is a relatively recent adaptation that distinguishes Yersinia pestis, the plague bacillus, from closely related enteric bacteria. Here, a plasmid-encoded phospholipase D (PLD), previously characterized as Yersinia murine toxin (Ymt), was shown to be required for survival of Y, pestis in the midgut of its principal vector, the rat flea Xenopsylla cheopis. Intracellular PLD activity appeared to protect Y. pestis from a cytotoxic digestion product of blood plasma in the flea gut. By enabling colonization of the flea midgut, acquisition of this PLD may have precipitated the transition of Y. pestis to obligate arthropod-borne transmission.

引用

页码：733 / 735

页数：3

共 27 条

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