Assembly and Patterning of vertebrate blood vessels

被引:9
作者
Bautch, VL
Ambler, CA
机构
[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
关键词
D O I
10.1016/j.tcm.2004.02.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The mechanisms that regulate blood vessel assembly at appropriate sites in the organism are poorly understood, yet understanding this regulation is critical to the ability to design therapeutics around vessel production in vivo. Classic embryologic studies have yielded descriptive analyses of vascular pattern formation, and they show that angioblasts and endothelial cells respond to environmental cues to assemble at precise embryologic sites. The present study incorporate a genetic model, the mouse, into these studies to obtain mechanistic information regarding vessel assembly and patterning. The data show that both embryo-derived and stem-cell-derived mouse angioblasts respond to host cues in the avian embryo and pattern properly, and also highlight a critical role for the vascular endothelial cell growth factor signaling pathway in these patterning events. (C) 2004, Elsevier Inc.
引用
收藏
页码:138 / 143
页数:6
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