Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH:ubiquinone oxidoreductase (complex I)

被引：22

作者：

Estornell, E ^{[1
]}

Tormo, JR ^{[1
]}

Cortes, D ^{[1
]}

机构：

[1] UNIV VALENCIA,FAC FARM,DEPT FARMACOL FARMACOGNOSIA & FARMACODINAMIA,E-46100 BURJASSOT,VALENCIA,SPAIN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 240卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism linking electron transport to proton translocation in the NADH:ubiquinone oxidoreductase (complex I of the mitochondrial respiratory chain) is still unclear. Inhibitors acting at different sites of the enzyme are powerful tools to clarify this mechanism. Up to now, a unique inhibitor, the Annonaceous acetogenin rolliniastatin-2, selectively blocks the most internal proton-translocation site. This study introduces cherimolin-1, a new acetogenin that inhibits the complex I with this special mode of action, which is more easily available from the plant material. Moreover, the mode of action of this scarce type of complex I inhibitor is further characterized. (C) 1997 Academic Press.

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页码：234 / 238

页数：5

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