A bioactive seco-rosane diterpenoid from Vellozia candida

被引：13

作者：

Valente, LMM

Gunatilaka, AAL

Kingston, DGI

Patitucci, ML

Pinto, AC

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV, DEPT CHEM, BLACKSBURG, VA 24061 USA

[2] UNIV FED RIO DE JANEIRO, CTR TECHNOL, INST QUIM, BR-21910240 BLACKSBURG, RJ, BRAZIL

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 05期

关键词：

D O I：

10.1021/np960695a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-directed fractionation of the bioactive alcoholic extracts of Vellozia candida yielded a new 6,7-seco-rosane diterpenoid, candidalactone (1), which showed moderate toxicity toward DNA repair-deficient mutants of Saccharomyces cerevisiae. Another new but inactive rosane diterpenoid, candidenodiol (3), was also obtained.

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页码：478 / 481

页数：4

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