Adverse effect of combination of chronic psychosocial stress and high fat diet on hippocampus-dependent memory in rats

被引:80
作者
Alzoubi, K. H. [2 ]
Abdul-Razzak, K. K. [2 ]
Khabour, O. F. [3 ]
Al-Tuweiq, G. M. [4 ]
Alzubi, M. A. [2 ]
Alkadhi, K. A. [1 ]
机构
[1] Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
[2] Jordan Univ Sci & Technol, Fac Pharm, Dept Clin Pharm, Irbid, Jordan
[3] Jordan Univ Sci & Technol, Dept Med Lab Sci, Fac Appl Med Sci, Irbid, Jordan
[4] Jordan Univ Sci & Technol, Fac Med, Dept Legal Med, Irbid, Jordan
关键词
Psychosocial stress; High fat diet; Hippocampal-dependent memory; Radial arm water maze; LONG-TERM POTENTIATION; HYPOTHYROIDISM-INDUCED IMPAIRMENT; SPATIAL WORKING-MEMORY; ARM WATER MAZE; SYNAPTIC PLASTICITY; NEUROTROPHIC FACTOR; CA1; REGION; BEHAVIORAL STRESS; KETOGENIC DIET; DENTATE GYRUS;
D O I
10.1016/j.bbr.2009.05.025
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The combined effects of high fat diet (HFD) and chronic stress on the hippocampus-de pendent spatial learning and memory were studied in rats using the radial arm water maze (RAWM). Chronic psychosocial stress and/or HFD were simultaneously administered for 3 months to young adult male Wister rats. In the RAWM, rats were subjected to 12 learning trials as well as short-term and long-term memory tests. This procedure was applied on a daily basis until the animal reaches days to criterion (DTC) in the 12th learning trial and in memory tests. DTC is the number of days that the animal takes to make zero error in two consecutive days. Groups were compared based on the number of errors per trial or test as well as on the DTC. Chronic stress, HFD and chronic stress/HFD animal groups showed impaired learning as indicated by committing significantly (P < 0.05) more errors than untreated control group in trials 6 through 9 of day 4. In memory tests, chronic stress, HFD and chronic stress/HFD groups showed significantly impaired performance compared to control group. Additionally, the stress/HFD was the only group that showed significantly impaired performance in memory tests on the 5th training day, suggesting more severe memory impairment in that group. Furthermore, DTC value for above groups indicated that chronic stress or HFD, alone, resulted in a mild impairment of spatial memory, but the combination of chronic stress and HFD resulted in a more severe and long-lasting memory impairment. The data indicated that the combination of stress and HFD produced more deleterious effects on hippocampal cognitive function than either chronic stress or HFD alone. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:117 / 123
页数:7
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