Changing the natural history of HIV disease

被引:105
作者
Feinberg, MB
机构
[1] Office of AIDS Research, National Institutes of Health, Building 31, Bethesda, MD 20892
关键词
D O I
10.1016/S0140-6736(96)06231-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Our understanding of the pathogenesis of AIDS has advanced considerably since the disease was first reported 15 years ago. We now know that the primary damage inflicted by HIV-1 is mainly brought about by active virus replication. With the advent of sensitive tools for monitoring HIV replication in vivo, an individual's risk of disease progression can be assessed early in the course of the infection and the efficacy of antiviral therapies can now be determined accurately and expeditiously. When used appropriately, potent combinations of antiviral drugs seem to be able to circumvent the inherent tendency of HIV-1 to generate drug-resistant viruses, the main reason for failure of all antiviral therapies, and are significantly more effective than earlier approaches. For the first time, rational approaches to contain and perhaps eliminate HIV-1 infection can be pursued.
引用
收藏
页码:239 / 246
页数:8
相关论文
共 48 条
  • [1] CLINICAL-EVALUATION OF BRANCHED DNA SIGNAL AMPLIFICATION FOR QUANTIFYING HIV TYPE-1 IN HUMAN PLASMA
    CAO, YZ
    HO, DD
    TODD, J
    KOKKA, R
    URDEA, M
    LIFSON, JD
    PIATAK, M
    CHEN, S
    HAHN, BH
    SAAG, MS
    SHAW, GM
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (03) : 353 - 361
  • [2] HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY
    COFFIN, JM
    [J]. SCIENCE, 1995, 267 (5197) : 483 - 489
  • [3] COOMBS RW, IN PRESS J INFECT DI
  • [4] Darby SC, 1996, LANCET, V347, P1573, DOI 10.1016/S0140-6736(96)91073-9
  • [5] GENOMIC STRUCTURE OF AN ATTENUATED QUASI-SPECIES OF HIV-1 FROM A BLOOD-TRANSFUSION DONOR AND RECIPIENTS
    DEACON, NJ
    TSYKIN, A
    SOLOMON, A
    SMITH, K
    LUDFORDMENTING, M
    HOOKER, DJ
    MCPHEE, DA
    GREENWAY, AL
    ELLETT, A
    CHATFIELD, C
    LAWSON, VA
    CROWE, S
    MAERZ, A
    SONZA, S
    LEARMONT, J
    SULLIVAN, JS
    CUNNINGHAM, A
    DWYER, D
    DOWTON, D
    MILLS, J
    [J]. SCIENCE, 1995, 270 (5238) : 988 - 991
  • [6] MASSIVE COVERT INFECTION OF HELPER T-LYMPHOCYTES AND MACROPHAGES BY HIV DURING THE INCUBATION PERIOD OF AIDS
    EMBRETSON, J
    ZUPANCIC, M
    RIBAS, JL
    BURKE, A
    RACZ, P
    TENNERRACZ, K
    HAASE, AT
    [J]. NATURE, 1993, 362 (6418) : 359 - 362
  • [7] Survival from early, intermediate, and late stages of HIV infection
    Enger, C
    Graham, N
    Peng, Y
    Chmiel, JS
    Kingsley, LA
    Detels, R
    Munoz, A
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (17): : 1329 - 1334
  • [8] FEINBERG MB, 1995, SCI AM MED, V7, P1
  • [9] GULLICK RM, 1996, 11 INT C AIDS VANC, P19
  • [10] Toward an understanding of the correlates of protective immunity to HIV infection
    Haynes, BF
    Pantaleo, G
    Fauci, AS
    [J]. SCIENCE, 1996, 271 (5247) : 324 - 328